Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure

What Was Tested

This randomized controlled trial paper looks at Peptide YY.

Malnutrition is very prevalent among patients with chronic renal failure.

The role of derangements in the gut-brain axis for regulation of appetite in the genesis of anorexia of these patients has not been adequately investigated.

Who Took Part

The study group was 10 patients.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized and crossover.

The patients were allocated by chance, so the Peptide YY group and the comparison group should start out alike.

In the crossover set-up each of the patients took both Peptide YY and the comparison in turn, acting as their own control.

What Was Measured

Following a randomized, crossover design, the researchers analysed plasma levels of peptide YY (PYY)(1-36) and PYY(3-36) both fasting and after a standardized oral mixed meal or intraperitoneal glucose infusion in 10 stable uraemic patients undergoing peritoneal dialysis and 8 healthy controls, matched for age, gender and body mass index.

The association of high levels of PYY(3-36) and normal levels of acylated ghrelin (when compared with healthy controls) configurated a markedly pro-anorexigenic pattern in patients.

The subject headings attached to it are Anorexia, Appetite, Case-Control Studies, Chronic Disease, Dialysis Solutions, Food, Formulated and Glucose.

What This Means in Plain Language

The paper is a randomized and crossover study of Peptide YY in 10 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2008 (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association), a journal based in England.

More context: the Peptide YY compound page, all human trials.