[Changes of plasma B-type natriuretic peptide level during non-invasive ventilation in treating acute left heart failure]

What Was Tested

This randomized controlled trial looks at BNP (Nesiritide).

To assess the changes of B-type natriuretic peptide (BNP) levels during noninvasive ventilation in treating acute left heart failure.

Who Took Part

The abstract describes 28 patients taking part.

PubMed indexes the participants as middle-aged adults, older adults and people over 80, both men and women.

Totally 28 patients with acute left heart failure were randomly assigned to group A (n = 13; without non-invasive ventilation) and group B (n = 15; undergoing non-invasive ventilation).

Another 10 healthy adults were enrolled as the normal control group.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Plasma BNP were obtained with ELISA before treatment and 3 and 7 hours after treatment.

What Was Measured

Topics PubMed links to this paper include Enzyme-Linked Immunosorbent Assay, Heart Failure, Intermittent Positive-Pressure Ventilation and Natriuretic Peptide, Brain.

What This Means in Plain Language

The paper is a randomized study of BNP (Nesiritide) in 28 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2008 (Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae), a journal based in China.

More context: the BNP (Nesiritide) compound page, all human trials.