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Bone densitometric and histomorphometric responses to sequential human parathyroid hormone (1-38) and salmon calcitonin in osteoporotic patients
Plain-language guide to PMID 1868270 (1991): randomized controlled trial study of Parathyroid Hormone (PTH 1-84) and Calcitonin, osteoporosis and bone density.
Key Facts
- PMID
- 1868270
- Journal
- Bone and mineral
- Year
- 1991
- Study type
- Randomized Controlled Trial
- Authors
- Hodsman AB et al. (4 authors)
- DOI
- 10.1016/0169-6009(91)90103-7
What This Study Did, in Plain Language
What Was Tested
Researchers studied Parathyroid Hormone (PTH 1-84) and Calcitonin in the context of osteoporosis and bone density in this randomized controlled trial publication.
Cyclical treatments of osteoporosis utilizing a skeletal Activator of bone remodelling, and sequential therapy with a Depressor to selectively block the resulting phase of osteoclastic resorption have been dubbed 'ADFR' therapy; there is usually a treatment Free interval while the activated bone multicellular units complete the remodelling cycle before the protocol is Repeated.
In this report an ADFR protocol was developed in which all patients received synthetic hPTH (1-38) for the first 14 days of a 100 day cycle.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
Half the patients received no other therapy (Group 1), but were followed closely with repeated vertebral bone mineral measurements over two full cycles.
How the Study Was Run
The design is described as randomized.
Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.
What Was Measured
The subject headings attached to it are Alkaline Phosphatase, Biopsy, Bone Density, Calcitonin, Osteogenesis, Osteoporosis and Parathyroid Hormone.
What This Means in Plain Language
The paper is a randomized study of Parathyroid Hormone (PTH 1-84) and Calcitonin in people with osteoporosis and bone density.
The publication is from 1991 (Bone and mineral), a journal based in Ireland.
More context: the Parathyroid Hormone (PTH 1-84) compound page and the Calcitonin compound page, Osteoporosis and bone density research.
Our Notes on the Compounds
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Calcitonin: A 32-amino-acid hormone that lowers blood calcium; salmon calcitonin (Miacalcin) has been used for Paget disease and osteoporosis.
Related Pages
- Osteoporosis and bone density research
- Parathyroid Hormone (PTH 1-84) in the library
- Calcitonin in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.