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Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women.
Plain-language guide to PMID 1883119 (1991): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 249 women.
Key Facts
- PMID
- 1883119
- Journal
- Annals of internal medicine
- Year
- 1991
- Study type
- Randomized Controlled Trial
- Authors
- Dawson-Hughes B et al. (6 authors)
- DOI
- 10.7326/0003-4819-115-7-505
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
To determine whether relative vitamin D deficiency during the winter months contributes to age-related bone loss and whether rates of change in hard- and soft-tissue mass vary during the year.
Who Took Part
The abstract describes 249 women taking part.
PubMed indexes the participants as middle-aged adults, women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the women and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Duplicate spine and whole-body scans were done by dual energy x-ray absorptiometry at 6-month intervals that were timed to periods when 25-hydroxyvitamin D levels were highest and lowest.
Period 1 was June-July to December-January and period 2 was December-January to the next June-July.
Serum parathyroid hormone and plasma 25-hydroxyvitamin D levels were measured during periods 1 and 2.
What Was Measured
The subject headings attached to it are Absorptiometry, Photon, Body Composition, Bone Density, Osteoporosis, Postmenopausal, Seasons, Spine and Vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 249 women.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 1991 (Annals of internal medicine), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.