Effect of the glycemic index of carbohydrates on day-long (10 h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin

What Was Tested

The paper reports a study of Ghrelin and Cholecystokinin (CCK), published as a randomized controlled trial.

To investigate the effect of a low and a high GI diet on day-long (10 h) blood concentrations of glucose, insulin, cholecystokinin (CCK) and ghrelin (GHR).

Why It Was Studied

The drive to eat may be mediated by postprandial changes in glucose, insulin and gut peptides.

Who Took Part

The age groups tagged for this paper are adults, men only.

Subjects (n=12) consumed a high and a low GI diet in a randomized, crossover design, consisting of four meals that were matched for macronutrients and fibre, and differed only in carbohydrate quality (GI).

How the Study Was Run

In design terms this was a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.

Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.

Blood was sampled every 30-60 min and assayed for glucose, insulin, CCK and GHR.

What Was Measured

Topics PubMed links to this paper include Appetite Regulation, Blood Glucose, Cholecystokinin, Dietary Carbohydrates, Energy Intake, Ghrelin and Glycemic Index.

What This Means in Plain Language

The paper is a randomized and crossover study of Ghrelin and Cholecystokinin (CCK).

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2009 (European journal of clinical nutrition), a journal based in England.

More context: the Ghrelin compound page and the Cholecystokinin (CCK) compound page, all human trials.