← Human Trials & Peer-Reviewed Studies
Beneficial effects of combination therapy with angiotensin II receptor blocker and angiotensin-converting enzyme inhibitor on vascular endothelial function.
Plain-language guide to PMID 18971536 (2008): randomized controlled trial of Amlodipine and Perindopril.
Key Facts
- PMID
- 18971536
- Journal
- Hypertension research : official journal of the Japanese Society of Hypertension
- Year
- 2008
- Study type
- Randomized Controlled Trial
- Authors
- Morimoto S et al. (5 authors)
- DOI
- 10.1291/hypres.31.1603
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Amlodipine and Perindopril, published as a randomized controlled trial.
The patients were evaluated before and after therapy to assess changes in blood pressure, flow-mediated vasodilation (a parameter of vascular endothelial function), and brachial-ankle pulse wave velocity (a parameter of arteriosclerosis).
Why It Was Studied
In the present study, the researchers evaluated the effect of treatment with the calcium channel blocker amlodipine or the angiotensin I-converting enzyme inhibitor perindopril on vascular endothelial function and arteriosclerosis in patients with essential hypertension who had already been receiving angiotensin receptor blocker monotherapy.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
The participants were allocated by chance, so the Amlodipine group and the comparison group should start out alike.
What Was Measured
In the present study, the researchers evaluated the effect of treatment with the calcium channel blocker amlodipine or the angiotensin I-converting enzyme inhibitor perindopril on vascular endothelial function and arteriosclerosis in patients with essential hypertension who had already been receiving angiotensin receptor blocker monotherapy.
Topics PubMed links to this paper include Amlodipine, Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Flow Velocity, Blood Pressure and Calcium Channel Blockers.
What This Means in Plain Language
The paper is a randomized study of Amlodipine and Perindopril.
The publication is from 2008 (Hypertension research : official journal of the Japanese Society of Hypertension), a journal based in England.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.