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Effect of superovulation with human menopausal gonadotropins on growth hormone levels in women.
Plain-language guide to PMID 1908478 (1991): parallel-group controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and HMG (Human Menopausal Gonadotropin) in 30 women.
Key Facts
- PMID
- 1908478
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 1991
- Study type
- Controlled Clinical Trial
- Authors
- Wilson EE et al. (4 authors)
- DOI
- 10.1210/jcem-73-3-511
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and HMG (Human Menopausal Gonadotropin), published as a controlled clinical trial.
The purpose of the present investigation was to define the relationship between serum GH and estradiol levels during the follicular phase in women with normal ovulatory menstrual cycles compared with that in women undergoing superovulation with human menopausal gonadotropins (hMG) alone or hMG plus GnRH agonists during treatment for infertility.
Why It Was Studied
GH synthesis and secretion are influenced by several factors, including age, body weight, and sex steroid hormones.
Endogenous and exogenous estrogens influence the circulating levels of GH.
Who Took Part
The abstract describes 30 women taking part.
The age groups tagged for this paper are adults, women only.
How the Study Was Run
The design is described as parallel-group.
The Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group and the comparison group ran side by side rather than switching.
What Was Measured
Endogenous and exogenous estrogens influence the circulating levels of GH.
Serum GH and estradiol levels were determined by immunoassay in eight women during the follicular phase of a spontaneous natural cycle (group I).
Topics PubMed links to this paper include Antineoplastic Agents, Estradiol, Follicular Phase, Gonadotropin-Releasing Hormone, Growth Hormone, Leuprolide and Menotropins.
What This Means in Plain Language
The paper is a parallel-group study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and HMG (Human Menopausal Gonadotropin) in 30 women.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1991 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the HMG (Human Menopausal Gonadotropin) compound page, all human trials.
Our Notes on the Compounds
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Related Pages
- Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library
- HMG (Human Menopausal Gonadotropin) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.