← Human Trials & Peer-Reviewed Studies
Randomized controlled trial to investigate the effects of growth hormone treatment on scoliosis in children with Prader-Willi syndrome.
Plain-language guide to PMID 19158197 (2009): multicenter randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 91 children.
Key Facts
- PMID
- 19158197
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- de Lind van Wijngaarden RF et al. (6 authors)
- DOI
- 10.1210/jc.2008-1844
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).
The aim was to study the effects of GH treatment on the onset of scoliosis and curve progression in children with PWS.
Why It Was Studied
Although reports about effects of GH treatment on scoliosis in children with PWS are limited, scoliosis is generally considered a contraindication for GH treatment.
Who Took Part
According to the abstract, 91 children were involved.
By PubMed's age tags, the people studied were infants, young children, children and teenagers, both men and women.
The researchers conducted a multicenter, randomized, controlled GH study in infants and prepubertal and pubertal children.
A total of 91 children with PWS (median age, 4.7 yr; interquartile range, 2.1-7.4) participated in the study.
How the Study Was Run
The researchers set it up as a randomized and multicenter study.
Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
More than one site took part, so the children came from several places.
Yearly, x-rays of the spine were taken, and height, weight, truncal lean body mass (with dual energy x-ray absorptiometry), and IGF-I were measured.
What Was Measured
Topics PubMed links to this paper include Body Mass Index, Disease Progression, Human Growth Hormone, Insulin-Like Growth Factor I, Prader-Willi Syndrome, Puberty and Radiography.
What This Means in Plain Language
The paper is a randomized and multicenter study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 91 children.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2009 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.