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Nocturnal profile of growth hormone secretion during sleep induced by zolpidem: a double-blind study in young adults and children.
Plain-language guide to PMID 1916651 (1991): double-blind controlled clinical trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 12 volunteers.
Key Facts
- PMID
- 1916651
- Journal
- Hormone research
- Year
- 1991
- Study type
- Controlled Clinical Trial
- Authors
- Colle M et al. (7 authors)
- DOI
- 10.1159/000181872
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as a controlled clinical trial.
Overnight blood sampling for repeated growth hormone (GH) assays, regarded as the most physiological assessment of GH status, may induce some disturbances in patients' sleep and then in the evaluation of GH secretion.
Who Took Part
The abstract describes 12 volunteers taking part.
By PubMed's age tags, the people studied were children, teenagers and adults, both men and women.
How the Study Was Run
The design is described as double-blind, placebo-controlled, crossover and parallel-group.
As a double-blind Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) group a baseline to be compared against.
Each person switched between Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and the comparison at some point, usually with a gap in between.
Groups ran in parallel: each of the volunteers stayed in one arm throughout.
What Was Measured
Overnight blood sampling for repeated growth hormone (GH) assays, regarded as the most physiological assessment of GH status, may induce some disturbances in patients' sleep and then in the evaluation of GH secretion.
PubMed files the paper under topics including Circadian Rhythm, Growth Hormone, Hypnotics and Sedatives, Pyridines, Sleep and Zolpidem.
What This Means in Plain Language
The paper is a double-blind, placebo-controlled and crossover study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 12 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 1991 (Hormone research), a journal based in Switzerland.
More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.
Our Notes on the Compound
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.