[Comparison of two sublingual types of desmopressin in 6-year-old and more children with primary nocturnal enuresis. About an international randomized cross-over study]

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

The principal objective of this study was to compare the preference of patients for the oral lyophilisate versus tablet.

Who Took Part

By PubMed's age tags, the people studied were children and teenagers, both men and women.

This open-label, randomized, cross-over study was undertaken at 26 centres across Europe and included patients with PNE.

Two hundred and fourteen patients aged 6 to 15 years were randomised (1:1) to receive the treatment in the order lyophilisate/tablet (n=108) or tablet/lyophilisate (n=106).

How the Study Was Run

The researchers set it up as a randomized, open-label and crossover study.

Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.

Being open-label, the Vasopressin study did not mask who received what.

In the crossover set-up each of the participants took both Vasopressin and the comparison in turn, acting as their own control.

What Was Measured

PubMed files the paper under topics including Administration, Sublingual, Antidiuretic Agents, Deamino Arginine Vasopressin, Nocturnal Enuresis and Patient Satisfaction.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Vasopressin and Desmopressin.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2009 (Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie), a journal based in France.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.