Growth hormone, menopause and ageing: no definite evidence for 'rejuvenation' with growth hormone.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this review publication.

Estrogens regulate growth hormone (GH) secretion and modulate the tissue responsiveness to GH.

After the menopause, and during ageing, a decline in GH secretion (somatopause) is physiologically observed.

Who the Included Studies Covered

PubMed indexes the participants as middle-aged adults, women only.

A systematic literature search was conducted in the PubMed database using the search terms 'Growth Hormone', 'Somatopause' and 'Menopause'.

How the Review Was Done

The search included full English articles covering the period 1972-2008.

The researchers selected 234 relevant citations.

The researchers also included three chapters from books.

What Was Measured

This article (i) provides a brief overview of the different regulators of GH secretion, (ii) reviews the mechanisms involved in age-related changes in GH concentrations, with particular emphasis on the interrelationships between menopause and GH, and (iii) discusses the interventions aimed at the restoration of GH and insulin-like growth factor (IGF-1) circulating levels.

PubMed files the paper under topics including Aging, Body Composition, Estrogen Replacement Therapy, Estrogens, Feedback, Physiological, Growth Hormone and Insulin-Like Growth Factor I.

What This Means in Plain Language

This is a review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2009 (Human reproduction update), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.