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Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid
Plain-language guide to PMID 19236375 (2009): crossover randomized controlled trial study of Vasopressin and Desmopressin in 116 women.
Key Facts
- PMID
- 19236375
- Journal
- British journal of haematology
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- Kouides PA et al. (12 authors)
- DOI
- 10.1111/j.1365-2141.2009.07610.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vasopressin and Desmopressin in this randomized controlled trial publication.
The optimal management of menorrhagia among women with abnormal laboratory haemostasis is uncertain.
In a crossover study, 116 women with menorrhagia [pictorial blood assessment chart (PBAC) score >100], negative gynaecological evaluation and abnormal laboratory haemostasis were randomly assigned to either intranasal desmopressin (IN-DDAVP) or tranexamic acid (TA) therapy for two menstrual cycles.
Who Took Part
The study group was 116 women.
By PubMed's age tags, the people studied were adults, women only.
Menstrual blood loss (MBL) was measured by PBAC scores at baseline and after each menstrual cycle.
Quality of life (QOL) was assessed with four validated instruments.
How the Study Was Run
In design terms this was a randomized and crossover study.
Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.
What Was Measured
In a crossover study, 116 women with menorrhagia [pictorial blood assessment chart (PBAC) score >100], negative gynaecological evaluation and abnormal laboratory haemostasis were randomly assigned to either intranasal desmopressin (IN-DDAVP) or tranexamic acid (TA) therapy for two menstrual cycles.
The subject headings attached to it are Antifibrinolytic Agents, Deamino Arginine Vasopressin, Headache, Hemostatics, Menorrhagia, Quality of Life and Tranexamic Acid.
What This Means in Plain Language
The paper is a randomized and crossover study of Vasopressin and Desmopressin in 116 women.
The publication is from 2009 (British journal of haematology), a journal based in England.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.