Effects of high sodium intake and diuretics on the circadian rhythm of blood pressure in type 2 diabetic patients treated with an angiotensin II receptor blocker.

What Was Tested

This randomized controlled trial looks at Diuretics and Hydrochlorothiazide in the context of low blood pressure and orthostatic hypotension.

The inhibition of the renin-angiotensin system in the diabetic condition was reported to enhance the sodium sensitivity of blood pressure.

Therefore, the researchers examined the effects of the amount of sodium intake or diuretics in patients with diabetes treated with an angiotensin receptor blocker.

Who Took Part

The study group was 2 patients.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Diuretics study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

At baseline, 24-h ambulatory blood pressure and 24-h urinary excretion of sodium were measured.

What Was Measured

The subject headings attached to it are Angiotensin II Type 1 Receptor Blockers, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Diabetes Mellitus, Type 2, Diuretics and Hydrochlorothiazide.

What This Means in Plain Language

The paper is a randomized study of Diuretics and Hydrochlorothiazide in 2 patients in people with low blood pressure and orthostatic hypotension.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2009 (Clinical and experimental nephrology), a journal based in Japan.

More context: Low blood pressure and orthostatic hypotension research.