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A preliminary report on the prognostic significance of preoperative brain natriuretic peptide and postoperative cardiac troponin in patients undergoing major vascular surgery
Plain-language guide to PMID 19299763 (2009): pilot randomized controlled trial study of BNP (Nesiritide) in 133 patients.
Key Facts
- PMID
- 19299763
- Journal
- Anesthesia and analgesia
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- Bolliger D et al. (7 authors)
- DOI
- 10.1213/ane.0b013e318194f3e6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.
In this study, the researchers evaluated the added value of preoperative BNP with postoperative cTn levels for the prediction of MACE in patients undergoing major vascular surgery.
Who Took Part
The abstract describes 133 patients taking part.
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
Patients were evaluated for MACE by hospital chart review during hospitalization and by telephone interviews 12 mo after surgery.
How the Study Was Run
The design is described as randomized and pilot.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
It is described as a pilot, a small early test of whether a larger BNP (Nesiritide) study would be practical.
Concentrations of BNP and cTn were determined before surgery, and concentrations of cTn were measured immediately after surgery and on postoperative days 1, 2, 3, and 7.
What Was Measured
In this study, the researchers evaluated the added value of preoperative BNP with postoperative cTn levels for the prediction of MACE in patients undergoing major vascular surgery.
PubMed files the paper under topics including Biomarkers, Cardiovascular Diseases, Kaplan-Meier Estimate, Natriuretic Peptide, Brain, Pilot Projects, Postoperative Care and Predictive Value of Tests.
What This Means in Plain Language
The paper is a randomized and pilot study of BNP (Nesiritide) in 133 patients.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2009 (Anesthesia and analgesia), a journal based in United States.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.