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Increased carbohydrate induced ghrelin secretion in obese vs. normal-weight adolescent girls
Plain-language guide to PMID 19325538 (2009): randomized controlled trial study of Ghrelin in 26 subjects.
Key Facts
- PMID
- 19325538
- Journal
- Obesity (Silver Spring, Md.)
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- Misra M et al. (5 authors)
- DOI
- 10.1038/oby.2009.86
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Ghrelin.
Their objective was to determine whether changes in levels of active ghrelin and peptide YY (PYY) differ in obese vs. normal-weight adolescent girls following specific macronutrient intake and predict hunger and subsequent food intake.
Why It Was Studied
Orexigenic and anorexigenic pathways mediate food intake and may be affected by meal composition.
The researchers enrolled 26 subjects: 13 obese and 13 normal-weight girls, 12-18 years old, matched for maturity (as assessed by bone age) and race.
Who Took Part
The study group was 26 subjects.
The age groups tagged for this paper are children and teenagers, women only.
Subjects were assigned a high-carbohydrate, high-protein, and high-fat breakfast in random order.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.
Active ghrelin and PYY were assessed for 4 h after breakfast and 1 h after intake of a standardized lunch.
Hunger was assessed using a standardized visual analog scale (VAS).
What Was Measured
The researchers enrolled 26 subjects: 13 obese and 13 normal-weight girls, 12-18 years old, matched for maturity (as assessed by bone age) and race.
No suppression in active ghrelin levels was noted following macronutrient intake in obese or normal-weight girls.
The subject headings attached to it are Adolescent Behavior, Biomarkers, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Eating and Feeding Behavior.
What This Means in Plain Language
The paper is a randomized study of Ghrelin in 26 subjects.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2009 (Obesity (Silver Spring, Md.)), a journal based in United States.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.