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Severe vitamin D deficiency among heart and liver transplant recipients.
Plain-language guide to PMID 19453643 (2010): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 19453643
- Journal
- Clinical transplantation
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Stein EM et al. (11 authors)
- DOI
- 10.1111/j.1399-0012.2009.00989.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Although patients with end-stage organ failure are at high risk for vitamin D deficiency because of limited sunlight exposure and hepatic dysfunction, few studies have measured 25-hydroxy vitamin D (25OHD) at the time of transplantation.
Who Took Part
The age groups tagged for this paper are young adults, adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized and double-blind.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
The researchers measured serum 25OHD immediately after transplantation in 69 heart and liver transplant recipients.
What Was Measured
Although patients with end-stage organ failure are at high risk for vitamin D deficiency because of limited sunlight exposure and hepatic dysfunction, few studies have measured 25-hydroxy vitamin D (25OHD) at the time of transplantation.
Topics PubMed links to this paper include Cross-Sectional Studies, Heart Failure, Heart Transplantation, Incidence, Liver Failure, Liver Transplantation and New York.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2010 (Clinical transplantation), a journal based in Denmark.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.