Utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing in guiding patients with a negative sestamibi scan for minimally invasive parathyroidectomy--a randomized controlled trial

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

The purpose of this study was to determine the utility of bilateral internal jugular venous sampling with rapid parathyroid hormone assay (BIJV-IOPTH) in comparison to endocrine surgeon-performed ultrasonography of the neck as an alternative localizing modality in guiding patients with primary hyperparathyroidism (pHPT) and negative sestamibi scans for minimally invasive parathyroidectomy (MIP).

Who Took Part

PubMed indexes the participants as adults, both men and women.

Seventy eight consenting patients with a negative subtraction sestamibi scan planned for parathyroidectomy underwent additional ultrasound parathyroid imaging and were randomized to undergo surgery without vs. with additional BIJV-IOPTH; n = 39 in each group.

The patients with a positive alternative imaging test were qualified for video-assisted MIP, whereas the others underwent open neck explorations.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.

The primary outcome measure was the number of patients with true-positive results of alternative imaging tests.

What Was Measured

Topics PubMed links to this paper include Adenoma, Blood Specimen Collection, Hyperplasia, Jugular Veins, Minimally Invasive Surgical Procedures, Monitoring, Intraoperative and Parathyroid Glands.

What This Means in Plain Language

The paper is a randomized study of Parathyroid Hormone (PTH 1-84).

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2009 (Langenbeck's archives of surgery), a journal based in Germany.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.