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Growth hormone (GH) treatment in short normal children: absence of influence of time of injection and resistance to GH autofeedback.

Plain-language guide to PMID 1955508 (1991): randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone) in 25 boys.

Key Facts

PMID
1955508
Journal
The Journal of clinical endocrinology and metabolism
Year
1991
Study type
Randomized Controlled Trial
Authors
Chanoine JP et al. (6 authors)
DOI
10.1210/jcem-73-6-1269

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone).

GH-releasing hormone (GHRH) testing was performed before and after 6 and 12 months of hGH therapy.

Who Took Part

The abstract describes 25 boys taking part.

PubMed indexes the participants as children, both men and women.

How the Study Was Run

The design is described as randomized.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

GH-releasing hormone (GHRH) testing was performed before and after 6 and 12 months of hGH therapy.

The subject headings attached to it are Antibody Formation, Body Height, Feedback, Growth Hormone, Growth Hormone-Releasing Hormone, Injections and Insulin-Like Growth Factor I.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and GHRH (Growth Hormone-Releasing Hormone) in 25 boys.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1991 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page and the GHRH (Growth Hormone-Releasing Hormone) compound page, all human trials.

Our Notes on the Compounds

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

GHRH (Growth Hormone-Releasing Hormone): The 44-amino-acid hypothalamic hormone that tells the pituitary to release growth hormone; sermorelin and tesamorelin are analogs.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.