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Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin
Plain-language guide to PMID 19604523 (2009): randomized controlled trial study of L-Carnitine in 2 patients.
Key Facts
- PMID
- 19604523
- Journal
- Metabolism: clinical and experimental
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- Malaguarnera M et al. (6 authors)
- DOI
- 10.1016/j.metabol.2009.05.014
- Registered trial
- NCT03696940
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of L-Carnitine, published as a randomized controlled trial.
Eighty diabetic patients were randomly assigned to 1 of 2 treatment groups for 3 months.
Who Took Part
According to the abstract, 2 patients were involved.
The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got L-Carnitine and who got the comparison, which limits bias.
A time span of 3 months appears in the methods.
What Was Measured
Topics PubMed links to this paper include Blood Glucose, Carnitine, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Lipids and Lipoproteins, LDL.
What This Means in Plain Language
The paper is a randomized study of L-Carnitine in 2 patients over 3 months.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2009 (Metabolism: clinical and experimental), a journal based in United States.
More context: the L-Carnitine compound page, all human trials.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.