Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study.

What Was Tested

This randomized controlled trial looks at Anti-Obesity Agents.

It was the purpose of the present investigation to extend the time course of measurement to 6 hours, and to include women within the design to determine if sex differences to treatment exist.

Why It Was Studied

However, in that investigation measurements ceased at 90 minutes post ingestion, with values for blood borne variables peaking at this time.

Who Took Part

The abstract describes 10 women taking part.

The age groups tagged for this paper are young adults, both men and women.

Ten men (24 +/- 4 yrs) and 10 women (22 +/- 2 yrs) ingested Meltdown or a placebo, using a randomized, cross-over design with one week separating conditions.

Blood samples were collected immediately before supplementation and at one hour intervals through 6 hours post ingestion.

How the Study Was Run

In design terms this was a randomized, placebo-controlled and crossover study.

The women were allocated by chance, so the Anti-Obesity Agents group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with Anti-Obesity Agents could be set against what happens without it.

Each person switched between Anti-Obesity Agents and the comparison at some point, usually with a gap in between.

A standard meal was provided after the hour 3 collection.

Samples were assayed for EPI, NE, glycerol, and FFA.

Five minute breath samples were collected at each time for measurement of metabolic rate and substrate utilization.

Area under the curve (AUC) was calculated.

Heart rate and blood pressure were recorded at all times.

What Was Measured

Data were also analyzed using a 2 (sex) x 2 (condition) x 7 (time) repeated measures analysis of variance, with Tukey post hoc testing.

However, in that investigation measurements ceased at 90 minutes post ingestion, with values for blood borne variables peaking at this time.

Topics PubMed links to this paper include Adipose Tissue, Analysis of Variance, Anti-Obesity Agents, Area Under Curve, Biomarkers, Caffeine and Catecholamines.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Anti-Obesity Agents in 10 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2009 (Lipids in health and disease), a journal based in England.

More context: all human trials.