Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate

What Was Tested

Researchers studied Therapeutic nicotine (patch, non-peptide) in this randomized controlled trial publication.

Delayed wound healing may explain postoperative tissue and wound dehiscence in smokers, but the effects of smoking and smoking cessation on the cellular mechanisms remain unclear.

Suction blisters were raised in 48 smokers and 30 never smokers.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some participants received a placebo instead of Therapeutic nicotine (patch, non-peptide), giving a reference point.

Transepidermal water loss (TEWL) was measured after 2, 4, and 7 days.

Then, the smokers were randomized to continuous smoking or abstinence with a transdermal nicotine patch or a placebo by concealed allocation.

Matrix metalloproteinase (MMP)-8 and MMP-1 levels in suction blister fluid were assessed by an enzyme-linked immunosorbent assay.

What Was Measured

The subject headings attached to it are Administration, Cutaneous, Collagenases, Epidermis, Exudates and Transudates, Matrix Metalloproteinase 1, Matrix Metalloproteinase 8 and Nicotine.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).

The publication is from 2009 (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society), a journal based in United States.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.