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Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients.
Plain-language guide to PMID 19667251 (2009): single-blind randomized controlled trial of Calcium Channel Blockers and Diuretics in 207 patients.
Key Facts
- PMID
- 19667251
- Journal
- Hypertension (Dallas, Tex. : 1979)
- Year
- 2009
- Study type
- Randomized Controlled Trial
- Authors
- Matsui Y et al. (7 authors)
- DOI
- 10.1161/HYPERTENSIONAHA.109.131466
- Registered trial
- NCT00607035
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Calcium Channel Blockers and Diuretics.
The aim of this study was to compare the effects between calcium channel blockers and diuretics when used in combination with angiotensin II receptor blocker on aortic systolic blood pressure (BP) and brachial ambulatory systolic BP.
Why It Was Studied
The researchers conducted a prospective, randomized, open-label, blinded end point study in 207 hypertensive patients (mean age: 68.4 years).
Who Took Part
The abstract describes 207 patients taking part.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, single-blind and open-label.
Because people in this Calcium Channel Blockers study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Only one side, usually the patients, was kept unaware of whether Calcium Channel Blockers was given.
Nothing was hidden in this open-label Calcium Channel Blockers study: the patients and staff both knew the treatment.
The central BP by radial artery tonometry, aortic pulse wave velocity, and ambulatory BP were assessed at baseline and 24 weeks later.
What Was Measured
The researchers conducted a prospective, randomized, open-label, blinded end point study in 207 hypertensive patients (mean age: 68.4 years).
PubMed files the paper under topics including Angiotensin II Type 1 Receptor Blockers, Aorta, Azetidinecarboxylic Acid, Blood Pressure, Calcium Channel Blockers, Dihydropyridines and Diuretics.
What This Means in Plain Language
The paper is a randomized, single-blind and open-label study of Calcium Channel Blockers and Diuretics in 207 patients.
The publication is from 2009 (Hypertension (Dallas, Tex. : 1979)), a journal based in United States.
More context: all human trials.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.