Supplementation of vitamin E, vitamin C, and zinc attenuates oxidative stress in burned children: a randomized, double-blind, placebo-controlled pilot study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The aim of this study was to investigate the effect of supplementation of vitamin E, vitamin C, and zinc on the oxidative stress in burned children.

Why It Was Studied

Total antioxidant capacity of plasma and malondialdehyde were used to monitor oxidative stress.

Who Took Part

According to the abstract, 32 patients were involved.

By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.

In a prospective double-blind placebo controlled pilot study, 32 patients were randomized as no supplementation (n = 15) or antioxidant supplementation (n = 17) groups.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and pilot study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.

The time of wound healing was evaluated as the main clinical feature.

What Was Measured

Topics PubMed links to this paper include Analysis of Variance, Ascorbic Acid, Burns, Chi-Square Distribution, Oxidative Stress, Pilot Projects and Statistics, Nonparametric.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 32 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2010 (Journal of burn care & research : official publication of the American Burn Association), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.