Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging

What Was Tested

Researchers studied Carnosine in the context of anti-aging & longevity in this randomized controlled trial publication.

The periorbital area is a key wrinkle-prone region, where the first signs of aging usually appear.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, women only.

Two double-blind, randomized, controlled, split-face studies (n = 42, Study 1; n = 35, Study 2) were conducted in women 30-70 years old with moderate to distinct periorbital wrinkles.

Four test products containing niacinamide, the peptides Pal-KT and Pal-KTTKS, and carnosine were used and included a daytime SPF 30 lotion also containing antioxidants, a night cream, an eye cream also containing caffeine, and a wrinkle treatment containing retinyl propionate.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The participants were allocated by chance, so the Carnosine group and the comparison group should start out alike.

As a double-blind Carnosine study, the assignments were hidden from both participants and investigators until the end.

The wrinkle treatment was only tested in Study 2.

The FOITS technique was used to measure changes in periorbital R(a) (mean roughness) and R(z) (average maximum roughness) at 2 and 4 weeks.

What Was Measured

The subject headings attached to it are Carnosine, Dimethylpolysiloxanes, Glycerol, Niacinamide, Oligopeptides, Skin Aging and Skin Diseases.

What This Means in Plain Language

The paper is a randomized and double-blind study of Carnosine in people with anti-aging & longevity.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2009 (Journal of cosmetic dermatology), a journal based in England.

More context: the Carnosine compound page, Anti-aging & longevity research.