Elevated saliva calcitonin gene-related peptide levels during acute migraine predict therapeutic response to rizatriptan

What Was Tested

Researchers studied CGRP (Calcitonin Gene-Related Peptide) in the context of migraine in this clinical trial publication.

(1) To measure calcitonin gene-related peptide (CGRP) levels in the saliva of individuals with migraine during the premonitory period, mild headache, moderate to severe headache, and post-resolution phases as compared with baseline (interictal) CGRP levels.

(2) To correlate response to rizatriptan administered during moderate headache with levels of CGRP levels measured in saliva.

Why It Was Studied

CGRP is implicated in the underlying pathophysiology of migraine.

To date no study has measured changes of saliva CGRP through the clinical evolution of a migraine attack and correlated saliva CGRP levels to clinical response to therapy.

Who Took Part

PubMed indexes the participants as young adults, adults and middle-aged adults, both men and women.

Responding subjects were defined as those who were symptom free at the time of the last collected saliva sample and did not have to rescue.

How the Study Was Run

Data were summarized using tables and descriptive statistics.

Statistical analysis was performed with the non-parametric signed-rank test using Minitab15 statistical software.

What Was Measured

To date no study has measured changes of saliva CGRP through the clinical evolution of a migraine attack and correlated saliva CGRP levels to clinical response to therapy.

PubMed files the paper under topics including Acute Disease, Biomarkers, Calcitonin Gene-Related Peptide, Drug Resistance, Migraine Disorders, Predictive Value of Tests and Saliva.

What This Means in Plain Language

This is a clinical trial of CGRP (Calcitonin Gene-Related Peptide) in people with migraine.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2009 (Headache), a journal based in United States.

More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.