Intranasal desmopressin versus blood transfusion in cirrhotic patients with coagulopathy undergoing dental extraction: a randomized controlled trial

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

Cirrhotic patients waiting for liver transplantation who need dental extractions are given fresh frozen plasma and/or platelets to correct coagulopathy.

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

Cirrhotic patients with platelet counts of 30,000 to 50,000/microL and/or international normalized ratio (INR) 2.0 to 3.0 were enrolled in a prospective, controlled, randomized clinical trial.

A standard oral and maxillofacial surgical treatment protocol was performed by the same surgeon.

How the Study Was Run

The design is described as randomized.

The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

Patients were followed for postextraction bleeding and side-effects over the next 24 to 48 hours.

What Was Measured

Topics PubMed links to this paper include Blood Coagulation Disorders, Blood Loss, Surgical, Blood Transfusion, Deamino Arginine Vasopressin, Hemostatics, International Normalized Ratio and Liver Cirrhosis.

What This Means in Plain Language

The paper is a randomized study of Vasopressin and Desmopressin.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2010 (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.