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Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus
Plain-language guide to PMID 20082586 (2010): single-blind randomized controlled trial of Ghrelin.
Key Facts
- PMID
- 20082586
- Journal
- Diabetes technology & therapeutics
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Rudovich N et al. (7 authors)
- DOI
- 10.1089/dia.2009.0129
What This Study Did, in Plain Language
What Was Tested
Researchers studied Ghrelin in this randomized controlled trial publication.
Ghrelin has been implicated in the regulation of feeding behavior and energy balance in humans.
Based on evidence that functional ATP-sensitive channels are present in ghrelin-producing cells, the researchers hypothesized that meglitinides may affect circulating ghrelin levels in subjects with type 2 diabetes.
Who Took Part
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults.
Ten control subjects without diabetes underwent a single LMCT without any medication.
How the Study Was Run
The design is described as randomized, single-blind, placebo-controlled and crossover.
Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
In this single-blind Ghrelin study one party knew the assignments and the other did not.
The comparison arm used a placebo, so changes seen with Ghrelin could be set against what happens without it.
Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.
What Was Measured
Based on evidence that functional ATP-sensitive channels are present in ghrelin-producing cells, the researchers hypothesized that meglitinides may affect circulating ghrelin levels in subjects with type 2 diabetes.
PubMed files the paper under topics including Benzamides, Blood Glucose, Body Mass Index, C-Peptide, Carbamates, Diabetes Mellitus, Type 2 and Eating.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of Ghrelin.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2010 (Diabetes technology & therapeutics), a journal based in United States.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.