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Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women
Plain-language guide to PMID 20155247 (2010): placebo-controlled randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 221 women.
Key Facts
- PMID
- 20155247
- Journal
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Bacon CJ et al. (6 authors)
- DOI
- 10.1007/s00198-009-1163-z
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.
Although many studies have addressed this question using cross-sectional data, the present study is one of few employing a prospective approach to determine 25(OH)D levels required to minimize PTH.
Why It Was Studied
Optimal levels of 25-hydroxyvitamin D [25(OH)D] were investigated in premenopausal Chinese women.
The upper level of 25-hydroxyvitamin D [25(OH)D] which constitutes a long-term bone health risk by causing elevated PTH levels is uncertain.
Who Took Part
The study group was 221 women.
PubMed indexes the participants as young adults and adults, women only.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Parathyroid Hormone (PTH 1-84) and who got the comparison, which limits bias.
The comparison arm used a placebo, so changes seen with Parathyroid Hormone (PTH 1-84) could be set against what happens without it.
What Was Measured
Optimal levels of 25-hydroxyvitamin D [25(OH)D] were investigated in premenopausal Chinese women.
The upper level of 25-hydroxyvitamin D [25(OH)D] which constitutes a long-term bone health risk by causing elevated PTH levels is uncertain.
Topics PubMed links to this paper include Cholecalciferol, Dairy Products, Food, Fortified, Parathyroid Hormone, Premenopause, Vitamin D and Vitamin D Deficiency.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Parathyroid Hormone (PTH 1-84) in 221 women.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2010 (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.