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Effect of glycomacropeptide fractions on cholecystokinin and food intake
Plain-language guide to PMID 20205966 (2010): double-blind randomized controlled trial study of Cholecystokinin (CCK).
Key Facts
- PMID
- 20205966
- Journal
- The British journal of nutrition
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Keogh JB et al. (6 authors)
- DOI
- 10.1017/S0007114510000280
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cholecystokinin (CCK) in this randomized controlled trial publication.
The objectives of the present study were to manufacture three glycoforms of GMP, minimally glycosylated GMP (3.5 (sd 0.1) % NeuNAc and 1.5 (sd 0.1) % Gal), glycosylated GMP (12.0 (sd 0.3) % NeuNAc and 4.2 (sd 0.2) % Gal) and a GMP-depleted whey protein concentrate, and to assess the effects of these fractions relative to glucose on CCK, subjective measures of satiety and food intake.
Why It Was Studied
Glycomacropeptide (GMP) is the hydrophilic 64-amino acid C-terminal glycopeptide released into cheese whey when kappa-casein is cleaved by chymosin.
GMP exists as a mixture of different glycoforms due to the carbohydrates sialic acid (N-acetylneuraminic acid, NeuNAc), galactose (Gal), galactosamine and glucosamine attached by O-glycosidic linkages.
Who Took Part
By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, men only.
Blood samples and subjective measures of satiety were collected before and at 15, 30, 60, 90, 120 and 180 min after the consumption of preload, and CCK levels were measured.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
The participants were allocated by chance, so the Cholecystokinin (CCK) group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Cholecystokinin (CCK), so expectations could not easily colour the readings.
What Was Measured
The subject headings attached to it are Appetite Regulation, Caseins, Cholecystokinin, Eating, Obesity, Overweight and Peptide Fragments.
What This Means in Plain Language
The paper is a randomized and double-blind study of Cholecystokinin (CCK).
The publication is from 2010 (The British journal of nutrition), a journal based in England.
More context: the Cholecystokinin (CCK) compound page, all human trials.
Our Notes on the Compound
Cholecystokinin (CCK): A gut and brain peptide hormone that stimulates gallbladder contraction and signals fullness.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.