Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism

What Was Tested

This randomized controlled trial paper looks at Therapeutic nicotine (patch, non-peptide).

Postoperative wound disruption and tissue-destructive disorders are more frequent in smokers than in nonsmokers.

Who Took Part

PubMed indexes the participants as adults, both men and women.

At 1, 4, 8, and 12 weeks, the wounds were excised and fixed for wound measurement, and blood was collected for measurement of vitamin C, procollagen I N-propeptide (PINP), matrix metalloproteinase 8 (MMP), MMP-9, neutrophils, and eosinophils.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Therapeutic nicotine (patch, non-peptide) and who got the comparison, which limits bias.

As a double-blind Therapeutic nicotine (patch, non-peptide) study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Therapeutic nicotine (patch, non-peptide) group a baseline to be compared against.

Full-thickness, 5-mm punch biopsy wounds were made lateral to the sacrum in 48 smokers and were randomized double-blinded to continuous smoking, abstinence with transdermal nicotine patch (TNP), or abstinence with placebo patch and 30 never smokers.

What Was Measured

PubMed files the paper under topics including Administration, Cutaneous, Ascorbic Acid, Biomarkers, Collagen, Matrix Metalloproteinase 8, Matrix Metalloproteinase 9 and Neutrophils.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2010 (Surgery), a journal based in United States.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.