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Comparative effects of norepinephrine and vasopressin on internal thoracic arterial graft flow after off-pump coronary artery bypass grafting
Plain-language guide to PMID 20434175 (2011): randomized controlled trial study of Vasopressin.
Key Facts
- PMID
- 20434175
- Journal
- The Journal of thoracic and cardiovascular surgery
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Park SY et al. (5 authors)
- DOI
- 10.1016/j.jtcvs.2010.03.012
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vasopressin.
Vasoconstrictors such as norepinephrine and vasopressin are commonly used to raise the blood pressure during myocardial revascularization.
The internal thoracic artery is commonly used for coronary artery grafting because of its long-term patency.
However, the internal thoracic artery is a living conduit that responds to vasoactive substances.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
Forty-one patients undergoing elective off-pump coronary artery bypass grafting participated in this study.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.
After the median sternotomy, the left internal thoracic artery was dissected with a pedicle and grafted to the left anterior descending artery.
After all anastomoses were performed and hemodynamic parameters were stable, the grafted internal thoracic arterial blood flow was measured by transit time flowmeter on the distal portion of the graft as a baseline.
Graft flow and hemodynamic variables were measured when mean arterial pressure reached the intended level.
What Was Measured
Topics PubMed links to this paper include Blood Flow Velocity, Blood Pressure, Coronary Artery Bypass, Off-Pump, Coronary Circulation, Elective Surgical Procedures, Hypotension and Infusions, Parenteral.
What This Means in Plain Language
The paper is a randomized study of Vasopressin.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2011 (The Journal of thoracic and cardiovascular surgery), a journal based in United States.
More context: the Vasopressin compound page, all human trials.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.