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Low-density lipoprotein apheresis decreases ferritin, transferrin and vitamin B12, which may cause anemia in serially treated patients.
Plain-language guide to PMID 20438534 (2010): controlled clinical trial of Cyanocobalamin (Vitamin B12) in 19 patients, anemia.
Key Facts
- PMID
- 20438534
- Journal
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
- Year
- 2010
- Study type
- Controlled Clinical Trial
- Authors
- Bramlage CP et al. (6 authors)
- DOI
- 10.1111/j.1744-9987.2009.00715.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12) in the context of anemia, published as a controlled clinical trial.
Since several different proteins are adsorbed by LDL apheresis beside pro-atherogenic lipoproteins, the researchers examined the modification of the full blood count, plasma iron, vitamin B12, folic acid, and hemolysis by LDL apheresis.
The patients' full blood count, iron metabolism (plasma iron, ferritin, transferrin, transferrin saturation), vitamins involved in erythropoiesis (vitamin B12 and folic acid), and markers of hemolysis (haptoglobin and free hemoglobin) were analyzed directly before and after LDL apheresis.
Who Took Part
The study group was 19 patients.
By PubMed's age tags, the people studied were middle-aged adults, both men and women.
Nineteen patients (55 (50-59) years, 4 female, 15 male) undergoing chronic LDL apheresis due to mixed dyslipidemia (N = 17), homozygous familiar hypercholesterolemia (N = 1) or isolated elevated lipoprotein(a) (N = 1) were included in this study.
How the Study Was Run
They were treated with direct adsorption of lipoproteins (DALI; N = 6), heparin-induced LDL-precipitation (HELP; N = 7) or double filtration plasmapheresis (DFPP; N = 6).
What Was Measured
The subject headings attached to it are Anemia, Blood Component Removal, Dyslipidemias, Erythropoiesis, Ferritins, Filtration and Heparin.
What This Means in Plain Language
This is a controlled clinical trial of Cyanocobalamin (Vitamin B12) in 19 patients in people with anemia.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2010 (Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy), a journal based in Australia.
More context: the Cyanocobalamin (Vitamin B12) compound page, Anemia research.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.