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Bioavailability of vitamin D3 in non-oily capsules: the role of formulated compounds and implications for intermittent replacement.
Plain-language guide to PMID 20485915 (2010): crossover randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 20485915
- Journal
- Arquivos brasileiros de endocrinologia e metabologia
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Coelho IM et al. (6 authors)
- DOI
- 10.1590/s0004-27302010000200022
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
To evaluate the bioavailability of vitamin D in capsules as compared with oily drops in nuns living in a closed community with very low sun exposure.
Samples were collected in the fasting state and at 4, 8, 12 and 24 hours following the administration of capsules and oily drops (both containing vitamin D3 66,000 UI plus vitamin A 13,200 UI) to determine serum 25 hydroxyvitamin D concentrations (25OHD), at baseline and 90 days after.
Who Took Part
By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, women only.
How the Study Was Run
The researchers set it up as a randomized and crossover study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.
A randomized, 2 x 2 crossover, open clinical trial was conducted, with 18 nuns aged between 20 and 75 years.
The evaluation was based on the maximum concentration (Cmax) and area under the curve (AUC0-24).
What Was Measured
The subject headings attached to it are Area Under Curve, Biological Availability, Capsules, Cholecalciferol, Therapeutic Equivalency, Vitamin D and Vitamin D Deficiency.
What This Means in Plain Language
The paper is a randomized and crossover study of Vitamin D, K2, Magnesium and Zinc.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2010 (Arquivos brasileiros de endocrinologia e metabologia), a journal based in Brazil.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.