Intravital staining with methylene blue in tympanoplasty

What Was Tested

The paper reports a study of Methylene blue (non-peptide stack partner), published as a randomized controlled trial.

Objective of the study is to investigate usefulness of the methylene blue staining for the operation of tympanoplasty in surgical training process with randomized, controlled trial.

Why It Was Studied

Two hospitals were involved: Department of Otolaryngology, Assaf Harofeh Medical Center, and Department of Otolaryngology Head and Neck Surgery, Soroka University Medical Center.

Tympanoplasty with graft placement was performed by young surgeons on 30 patients (30 ears) with anterior perforations using intraoperative staining of tympanoplasty grafts with methylene blue (Group 1).

Who Took Part

The study group was 30 patients.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Methylene blue (non-peptide stack partner) and who got the comparison, which limits bias.

What Was Measured

Topics PubMed links to this paper include Audiometry, Pure-Tone, Auditory Threshold, Cohort Studies, Graft Survival, Hearing Loss, Conductive, Methylene Blue and Myringoplasty.

What This Means in Plain Language

The paper is a randomized study of Methylene blue (non-peptide stack partner) in 30 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2010 (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery), a journal based in Germany.

More context: the Methylene blue (non-peptide stack partner) compound page, all human trials.