Vitamin D insufficiency defined by serum 25-hydroxyvitamin D and parathyroid hormone before and after oral vitamin D₃ load in Japanese subjects

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this clinical trial publication.

To determine the threshold serum 25(OH)D to maintain normal calcium availability without elevation in serum parathyroid hormone (PTH) among Japanese subjects with various calcium intakes, the researchers conducted a multicenter prospective open-labeled study.

Why It Was Studied

Vitamin D insufficiency is a risk for both skeletal and nonskeletal health.

However, some ambiguity remains about threshold serum 25(OH)D for vitamin D insufficiency.

Who Took Part

The study group was 107 subjects.

PubMed indexes the participants as adults, middle-aged adults, older adults and people over 80, both men and women.

Serum 25(OH)D, PTH, calcium, phosphate, and magnesium were measured before and after vitamin D₃ supplementation.

How the Study Was Run

In design terms this was an open-label and multicenter study.

Everyone knew when Parathyroid Hormone (PTH 1-84) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Running at several centres spread the Parathyroid Hormone (PTH 1-84) study over different clinics and patient groups.

Calcium intake was assessed by questionnaires.

What Was Measured

Topics PubMed links to this paper include Cholecalciferol, Osteoporosis, Parathyroid Hormone, Vitamin D and Vitamin D Deficiency.

What This Means in Plain Language

The paper is an open-label and multicenter study of Parathyroid Hormone (PTH 1-84) in 107 subjects.

The publication is from 2011 (Journal of bone and mineral metabolism), a journal based in Japan.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.