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Preference for formulations containing calcium and vitamin D(3) in childhood: a randomized-sequence, open-label trial.
Plain-language guide to PMID 20637962 (2010): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 20637962
- Journal
- Clinical therapeutics
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Bianchetti AA et al. (6 authors)
- DOI
- 10.1016/j.clinthera.2010.06.006
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The aim of this study was to compare the preference of Swiss children at risk for low bone mass for either a single-serving sachet or a suspension containing calcium and vitamin D(3).
Why It Was Studied
Children who experience adverse reactions to cow's milk or who have diseases predisposing them to low bone mass are often prescribed a supplementation of calcium and vitamin D(3), but adherence can be poor.
Age-specific preferences for different formulations may exist and at least partially explain poor compliance.
Who Took Part
By PubMed's age tags, the people studied were children and teenagers, both men and women.
Two different commercial formulations containing calcium and vitamin D(3), either as a lemon-flavored single-serving sachet or as a banana-flavored commercial suspension, were tested for preference by means of a 5-point facial hedonic scale in children aged 4 to 7 and 8 to 11 years.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
A concealed random allocation procedure was used.
The investigator asking about preference was blinded to the sequence.
What Was Measured
Topics PubMed links to this paper include Bone Density, Calcium, Cholecalciferol, Dietary Supplements, Patient Preference and Switzerland.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2010 (Clinical therapeutics), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.