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A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis
Plain-language guide to PMID 20661580 (2011): randomized controlled trial study of Triptorelin in 144 women, endometriosis.
Key Facts
- PMID
- 20661580
- Journal
- Archives of gynecology and obstetrics
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Alborzi S et al. (6 authors)
- DOI
- 10.1007/s00404-010-1599-6
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Triptorelin in the context of endometriosis, published as a randomized controlled trial.
To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptorelin) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis.
Who Took Part
According to the abstract, 144 women were involved.
PubMed indexes the participants as adults, women only.
In a prospective randomized clinical trial, after treatment of 144 infertile women in their reproductive age by laparoscopy (whose endometriosis was confirmed by prior laparoscopy), they were divided into 3 groups: group 1 (47 cases) who received letrozole for 2 months, group 2 (40 patients) who were prescribed triptorelin for 2 months and group 3 who were 57 patients in the control group and did not receive any medication.
How the Study Was Run
The design is described as randomized.
The women were allocated by chance, so the Triptorelin group and the comparison group should start out alike.
The timeline in the abstract includes 2 months.
The researchers followed up each group at least for 12 months after their restoration of regular cycle.
What Was Measured
Topics PubMed links to this paper include Aromatase Inhibitors, Endometriosis, Gonadotropin-Releasing Hormone, Infertility, Female, Laparoscopy, Letrozole and Nitriles.
What This Means in Plain Language
The paper is a randomized study of Triptorelin in 144 women in people with endometriosis over 2 months.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2011 (Archives of gynecology and obstetrics), a journal based in Germany.
More context: the Triptorelin compound page, Endometriosis research.
Our Notes on the Compound
Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.