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Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects
Plain-language guide to PMID 20738316 (2010): double-blind randomized controlled trial study of Ghrelin.
Key Facts
- PMID
- 20738316
- Journal
- Clinical endocrinology
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Huda MS et al. (8 authors)
- DOI
- 10.1111/j.1365-2265.2010.03865.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Ghrelin, published as a randomized controlled trial.
Ghrelin inhibits sympathetic nervous system (SNS) activity in rodents.
Who Took Part
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
Seven lean [mean body mass index (BMI) 23·6 ± 0·9 kg/m(2) ], seven morbidly obese (mean BMI 50·9 ± 4·4 kg/m(2) ) and seven post-gastrectomy subjects (mean BMI 22·0 ± 1·1 kg/m(2) ).
Subjects had a fixed calorie meal and a free choice buffet during the infusion.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and crossover study.
Because people in this Ghrelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on Ghrelin, so expectations could not easily colour the readings.
Some participants received a placebo instead of Ghrelin, giving a reference point.
Each person switched between Ghrelin and the comparison at some point, usually with a gap in between.
Heart rate variability (HRV) was measured.
Total power (TP) represents overall autonomic function, low-frequency (LF) power represents sympathetic and parasympathetic activity, and high-frequency (HF) power represents parasympathetic activity.
What Was Measured
The subject headings attached to it are Autonomic Nervous System, Blood Glucose, Blood Pressure, Gastrectomy, Ghrelin, Heart Rate and Insulin.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Ghrelin.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2010 (Clinical endocrinology), a journal based in England.
More context: the Ghrelin compound page, all human trials.
Our Notes on the Compound
Ghrelin: A 28-amino-acid stomach hormone that signals hunger and triggers growth hormone release; studied in human trials as an infusion.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.