A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans

What Was Tested

The paper reports a study of GIP (Gastric Inhibitory Polypeptide) in the context of insulin resistance, prediabetes & type 2 diabetes, published as a randomized controlled trial.

The researchers examined the effect of a low-glycemic index (GI) diet and exercise intervention on glucose metabolism and insulin secretion in obese, prediabetic individuals.

Why It Was Studied

The optimal lifestyle intervention that reverses diabetes risk factors is not known.

Who Took Part

By PubMed's age tags, the people studied were older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got GIP (Gastric Inhibitory Polypeptide) and who got the comparison, which limits bias.

Body composition (measured by using dual-energy X-ray absorptiometry and computed tomography), insulin sensitivity (measured with a hyperinsulinemic euglycemic clamp with [6,6-(2)H(2)]-glucose), and oral glucose-induced insulin and incretin hormone secretion were examined.

What Was Measured

Topics PubMed links to this paper include Adiposity, Combined Modality Therapy, Exercise, Gastric Inhibitory Polypeptide, Glucose Tolerance Test, Glycemic Index and Hyperinsulinism.

What This Means in Plain Language

The paper is a randomized study of GIP (Gastric Inhibitory Polypeptide) in people with insulin resistance, prediabetes & type 2 diabetes.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2010 (The American journal of clinical nutrition), a journal based in United States.

More context: the GIP (Gastric Inhibitory Polypeptide) compound page, Insulin resistance, prediabetes & type 2 diabetes research.