Pregnancy rate and ovarian hyperstimulation after luteal human chorionic gonadotropin in in vitro fertilization stimulated with gonadotropin-releasing hormone analog and menotropins

Plain-language guide to PMID 2104811 (1990): randomized controlled trial study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin).

Key Facts

PMID: 2104811
Journal: Fertility and sterility
Year: 1990
Study type: Randomized Controlled Trial
Authors: Herman A et al. (6 authors)
DOI: 10.1016/s0015-0282(16)53222-1

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin), published as a randomized controlled trial.

Nine patients of Group A conceived as compared with 3 in Group B.

Five patients, all in Group A, developed ovarian hyperstimulation syndrome (OHSS) (3 moderate and 2 severe forms).

Who Took Part

PubMed tags the participants as women only.

The value of luteal phase supplementation with human chorionic gonadotropin (hCG) was assessed after a combined protocol of ovarian stimulation, using a long acting gonadotropin releasing hormone analog (GnRH-a) and human menopausal gonadotropins (hMG), in a randomized prospective study of 36 consecutive cycles in an in vitro fertilization (IVF) program.

The patients were allocated on the transfer day to either luteal phase supplementation with hCG (Group A, n = 18) or none (Group B, n = 18).

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got hCG (human chorionic gonadotropin) and who got the comparison, which limits bias.

What Was Measured

PubMed files the paper under topics including Chorionic Gonadotropin, Embryo Transfer, Estradiol, Fertilization in Vitro, Gonadotropin-Releasing Hormone, Menotropins and Menstruation.

What This Means in Plain Language

The paper is a randomized study of hCG (human chorionic gonadotropin) and HMG (Human Menopausal Gonadotropin).

The publication is from 1990 (Fertility and sterility), a journal based in United States.

More context: the hCG (human chorionic gonadotropin) compound page and the HMG (Human Menopausal Gonadotropin) compound page, all human trials.

Our Notes on the Compounds

hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.

HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.

Triptorelin: A 10-amino-acid GnRH analog (Trelstar, Decapeptyl, Triptodur) used in prostate cancer, early puberty and fertility protocols.

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.