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Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients
Plain-language guide to PMID 21077943 (2011): randomized controlled trial of L-Carnitine in 2 patients.
Key Facts
- PMID
- 21077943
- Journal
- Fundamental & clinical pharmacology
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Derosa G et al. (8 authors)
- DOI
- 10.1111/j.1472-8206.2010.00888.x
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at L-Carnitine.
The researchers evaluated the following parameters at baseline and after 3, 6, 9, and 12 months: body weight, body mass index (BMI), glycated hemoglobin (HbA(1c) ), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), adiponectin (ADN), leptin, tumor necrosis factor-α (TNF-α), vaspin, and high-sensitivity C-reactive protein (Hs-CRP).
Who Took Part
The abstract describes 2 patients taking part.
By PubMed's age tags, the people studied were middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this L-Carnitine study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
The researchers evaluated the following parameters at baseline and after 3, 6, 9, and 12 months: body weight, body mass index (BMI), glycated hemoglobin (HbA(1c) ), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), adiponectin (ADN), leptin, tumor necrosis factor-α (TNF-α), vaspin, and high-sensitivity C-reactive protein (Hs-CRP).
PubMed files the paper under topics including Adiponectin, Anti-Inflammatory Agents, Anti-Obesity Agents, Blood Glucose, Body Mass Index, C-Reactive Protein and Carnitine.
What This Means in Plain Language
The paper is a randomized study of L-Carnitine in 2 patients.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2011 (Fundamental & clinical pharmacology), a journal based in England.
More context: the L-Carnitine compound page, all human trials.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.