The effect of HCG supplementation after combined GnRH agonist/HMG treatment in an IVF programme.

What Was Tested

Researchers studied Chorionic Gonadotropin in this randomized controlled trial publication.

The necessity of luteal-phase supplementation in an IVF programme is of continuing interest.

After ovarian stimulation with GnRH agonist/HMG, the luteal phase seems to be inadequate, but in a previous study the researchers did not find evidence to support the need for oral progesterone supplementation.

Who Took Part

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and multicenter.

Random assignment meant chance, not the researchers, decided who got Chorionic Gonadotropin and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Chorionic Gonadotropin, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Chorionic Gonadotropin could be set against what happens without it.

More than one site took part, so the participants came from several places.

What Was Measured

Topics PubMed links to this paper include Chorionic Gonadotropin, Embryo Transfer, Fertilization in Vitro, Menotropins, Pituitary Hormone-Releasing Hormones and Randomized Controlled Trials as Topic.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Chorionic Gonadotropin.

The publication is from 1990 (Human reproduction (Oxford, England)), a journal based in England.

More context: the related hCG (human chorionic gonadotropin) library page, all human trials.