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The effect of three different rotary instrumentation systems on substance P and calcitonin gene-related peptide expression in human periodontal ligament
Plain-language guide to PMID 21092809 (2010): randomized controlled trial of CGRP (Calcitonin Gene-Related Peptide) and Substance P.
Key Facts
- PMID
- 21092809
- Journal
- Journal of endodontics
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Caviedes-Bucheli J et al. (7 authors)
- DOI
- 10.1016/j.joen.2010.08.043
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at CGRP (Calcitonin Gene-Related Peptide) and Substance P.
The purpose of this study was to quantify the effect of three different rotary root canal preparation systems on substance P and calcitonin gene-related peptide expression in healthy human periodontal ligament.
Who Took Part
The age groups tagged for this paper are teenagers, young adults and adults.
Fifty periodontal ligament samples were obtained from healthy premolars in which extraction was indicated for orthodontic reasons.
Before extraction, 40 of these premolars were equally divided into four groups, and root canals were prepared using four different systems: the ProTaper Universal rotary system, the RaCe rotary system, the Mtwo rotary system, and the hand instrumentation technique.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got CGRP (Calcitonin Gene-Related Peptide) and who got the comparison, which limits bias.
The remaining 10 healthy premolars that were extracted without treatment served as a negative control group.
All periodontal ligament samples were processed, and SP and CGRP were measured by radioimmunoassay.
What Was Measured
The subject headings attached to it are Bicuspid, Calcitonin Gene-Related Peptide, Dental Instruments, Endpoint Determination, Neurogenic Inflammation, Periapical Periodontitis and Periodontal Ligament.
What This Means in Plain Language
The paper is a randomized study of CGRP (Calcitonin Gene-Related Peptide) and Substance P.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2010 (Journal of endodontics), a journal based in United States.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page and the Substance P compound page, all human trials.
Our Notes on the Compounds
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Substance P: An 11-amino-acid neuropeptide involved in pain signaling and inflammation; given in research studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.