Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle.

What Was Tested

This randomized controlled trial looks at Angiotensin II Type 1 Receptor Blockers.

Who Took Part

The age groups tagged for this paper are adults, both men and women.

The researchers designed a multicenter, prospective, randomized, double-blind, placebo-controlled trial studying the effect of valsartan in patients with a systemic right ventricle due to a congenitally or surgically corrected transposition of the great arteries.

The primary end point is the change in right ventricular ejection fraction as measured by cardiovascular magnetic resonance or multidetector row cardiac computed tomography in case of pacemaker patients.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and multicenter.

Random assignment meant chance, not the researchers, decided who got Angiotensin II Type 1 Receptor Blockers and who got the comparison, which limits bias.

Neither the participants nor the staff measuring them knew who was on Angiotensin II Type 1 Receptor Blockers, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Angiotensin II Type 1 Receptor Blockers could be set against what happens without it.

More than one site took part, so the participants came from several places.

What Was Measured

PubMed files the paper under topics including Angiotensin II Type 1 Receptor Blockers, Heart Atria, Magnetic Resonance Imaging, Stroke Volume, Tetrazoles, Tomography, X-Ray Computed and Valine.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II Type 1 Receptor Blockers.

Results are reported in around 1 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2010 (American heart journal), a journal based in United States.

More context: all human trials.