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Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans
Plain-language guide to PMID 21123762 (2011): single-blind randomized controlled trial study of Vasopressin and ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 21123762
- Journal
- American journal of physiology. Regulatory, integrative and comparative physiology
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Matsukawa T et al. (2 authors)
- DOI
- 10.1152/ajpregu.00324.2010
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vasopressin and ANP (Atrial Natriuretic Peptide).
The researchers investigated the effect of the intravenous infusion of atrial natriuretic peptide (ANP) on the response of plasma arginine vasopressin (AVP) levels to intravenous infusion of angiotensin II (ANG II) in healthy individuals.
Because the elevation in blood pressure could have potentially inhibited AVP secretion via baroreceptor reflexes, the effect of ANG II on blood pressure was attenuated by the simultaneous infusion of nitroprusside.
Who Took Part
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The researchers set it up as a randomized and single-blind study.
Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.
In this single-blind Vasopressin study one party knew the assignments and the other did not.
What Was Measured
The researchers investigated the effect of the intravenous infusion of atrial natriuretic peptide (ANP) on the response of plasma arginine vasopressin (AVP) levels to intravenous infusion of angiotensin II (ANG II) in healthy individuals.
Topics PubMed links to this paper include Angiotensin II, Atrial Natriuretic Factor, Baroreflex, Blood Pressure, Central Venous Pressure, Neurophysins and Nitroprusside.
What This Means in Plain Language
The paper is a randomized and single-blind study of Vasopressin and ANP (Atrial Natriuretic Peptide).
The publication is from 2011 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.
More context: the Vasopressin compound page and the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
- Vasopressin in the library
- ANP (Atrial Natriuretic Peptide) in the library
- Angiotensin II in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.