← Human Trials & Peer-Reviewed Studies
Vitamin D supplementation and bone mass accrual in underprivileged adolescent Indian girls.
Plain-language guide to PMID 21147706 (2010): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 21147706
- Journal
- Asia Pacific journal of clinical nutrition
- Year
- 2010
- Study type
- Randomized Controlled Trial
- Authors
- Khadilkar AV et al. (7 authors)
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The researchers conducted a pilot; double blind randomised controlled trial to investigate the effect of vitamin D supplementation on bone mineral content in underprivileged adolescent girls, in Pune, India.
Why It Was Studied
Vitamin D deficiency is common among children and adolescents in India, in spite of abundant sunshine.
Outcome measures included change in serum 25-hydroxyvitamin D, size adjusted bone area and bone mineral content at total body and lumbar spine.
Who Took Part
By PubMed's age tags, the people studied were teenagers, women only.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and pilot study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
Outcome measures included change in serum 25-hydroxyvitamin D, size adjusted bone area and bone mineral content at total body and lumbar spine.
PubMed files the paper under topics including Biomarkers, Bone Density, Bone Density Conservation Agents, Bone Remodeling, Bone and Bones, Calcium Carbonate and Dietary Supplements.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2010 (Asia Pacific journal of clinical nutrition), a journal based in China.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.