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Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance.
Plain-language guide to PMID 21243486 (2011): double-blind randomized controlled trial of Therapeutic nicotine (patch, non-peptide) in 41 participants.
Key Facts
- PMID
- 21243486
- Journal
- Psychopharmacology
- Year
- 2011
- Study type
- Randomized Controlled Trial
- Authors
- Warbrick T et al. (8 authors)
- DOI
- 10.1007/s00213-010-2145-8
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.
Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine.
Who Took Part
According to the abstract, 41 participants were involved.
PubMed indexes the participants as young adults, adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Therapeutic nicotine (patch, non-peptide) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.
In the crossover set-up each of the participants took both Therapeutic nicotine (patch, non-peptide) and the comparison in turn, acting as their own control.
What Was Measured
Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine.
The subject headings attached to it are Analysis of Variance, Brain, Brain Mapping, Choice Behavior, Functional Laterality, Image Processing, Computer-Assisted and Magnetic Resonance Imaging.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide) in 41 participants.
The publication is from 2011 (Psychopharmacology), a journal based in Germany.
More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.