Correlation of plasma copeptin and vasopressin concentrations in hypo-, iso-, and hyperosmolar States

What Was Tested

The paper reports a study of Vasopressin, published as a clinical trial.

To correlate plasma copeptin with plasma osmolality and vasopressin concentrations in healthy subjects during iso-, hypo-, and hyperosmolar states.

Why It Was Studied

Copeptin, the C-terminal moiety of provasopressin, is cosecreted with vasopressin.

Copeptin may be a useful parameter to characterize disorders of water homeostasis and can be readily measured in plasma or serum.

Who Took Part

The abstract describes 20 volunteers taking part.

By PubMed's age tags, the people studied were young adults and adults, both men and women.

How the Study Was Run

Correlation coefficients were determined between plasma osmolalites and copeptin and vasopressin concentrations, as well as between vasopressin and copeptin concentrations.

What Was Measured

Copeptin may be a useful parameter to characterize disorders of water homeostasis and can be readily measured in plasma or serum.

However, it is unknown to date how circulating copeptin and vasopressin levels correlate at different plasma osmolalites.

PubMed files the paper under topics including Glycopeptides, Health Status, Hypotonic Solutions, Osmolar Concentration, Saline Solution, Hypertonic, Vasopressins and Water.

What This Means in Plain Language

This is a clinical trial of Vasopressin in 20 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2011 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vasopressin compound page, all human trials.