Genetics of GHRH, GHRH-receptor, GH and GH-receptor: its impact on pharmacogenetics.

What It Covers

This review looks at Human Growth Hormone.

When a child is not following the normal, predicted growth curve, an evaluation for underlying illnesses and central nervous system abnormalities is required and, appropriate consideration should be given to genetic defects causing GH deficiency (GHD).

Because Insulin-like-Growth Factor-I (IGF-I) plays a pivotal role, GHD could also be considered as a form of IGF-I deficiency (IGFD).

Who the Included Studies Covered

By PubMed's age tags, the people studied were children.

What Was Measured

When a child is not following the normal, predicted growth curve, an evaluation for underlying illnesses and central nervous system abnormalities is required and, appropriate consideration should be given to genetic defects causing GH deficiency (GHD).

Although IGFD can develop at any level of the GHRH-GH-IGF axis, a differentiation should be made between GHD (absent to low GH in circulation) and IGFD (normal to high GH in circulation).

Topics PubMed links to this paper include Dwarfism, Pituitary, Growth Disorders, Growth Hormone-Releasing Hormone, Human Growth Hormone, Insulin-Like Growth Factor I, Mice and Mutation.

What This Means in Plain Language

This is a review of Human Growth Hormone.

The publication is from 2011 (Best practice & research. Clinical endocrinology & metabolism), a journal based in Netherlands.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.