Haemostatic changes during hormone manipulation in advanced prostate cancer: a comparison of DES [amount hidden] and goserelin [amount hidden]/month

What Was Tested

This randomized controlled trial looks at Goserelin and Buserelin.

In 22 patients from the two arms of the study regular assessments were made of the effect of these hormone treatments on the haemostatic system.

Selection of those patients with no recent surgical intervention and those on no drugs liable to interfere with the haemostatic mechanism was done at entry, in order to remove bias and achieve comparable groups.

Who Took Part

The study group was 22 patients.

By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, men only.

How the Study Was Run

The researchers set it up as a randomized study.

Because people in this Goserelin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

In 22 patients from the two arms of the study regular assessments were made of the effect of these hormone treatments on the haemostatic system.

PubMed files the paper under topics including Antithrombin III, Buserelin, Diethylstilbestrol, Goserelin, Hemostasis and Prostatic Neoplasms.

What This Means in Plain Language

The paper is a randomized study of Goserelin and Buserelin in 22 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1990 (European journal of cancer (Oxford, England : 1990)), a journal based in England.

More context: the Goserelin compound page and the Buserelin compound page, all human trials.